Tumor suppressors revival in CLL

Tumor suppressors revival in CLL

13q14 deletions in CLL involve cooperating tumor suppressors.

B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia. 13q14 deletions are most common chromosomal alterations in CLL. We previously reported that miR-15/16 is a target of 13q14 deletions and plays a tumor suppressor role by targeting BCL2. Because DLEU7 is located near miR-15/16 and is also positioned within a minimal deleted region, we investigated whether DLEU7 could al...

Tumor suppressors: enhancers or suppressors of regeneration?

Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essentia...

Oncogenes and Tumor Suppressors

Our understanding of estrogen (17b-estradiol, E2) receptor biology has evolved in recent years with the discovery and characterization of a 7-transmembrane-spanning G protein–coupled estrogen receptor (GPER/GPR30) and the development of GPER-selective functional chemical probes. GPER is highly expressed in certain breast, endometrial, and ovarian cancers, establishing the importance of noninvas...

Networks of tumor suppressors

The concept of tumor suppressor networks comes as a logical consequence of the increasing understanding of the biology of tumor suppressor genes and oncogenes. Indeed, it has been gratifying to realize during the past decade that the products of tumor suppressor genes and oncogenes are often involved in the kind of guardian–delinquent relationship, or cat-and-mouse game suggested by the genetic...